- Saint Vincent College
- 300 Fraser Purchase Road, Latrobe, PA, 15650
- Saks Building
- 513 Smithfield Street, Pittsburgh, PA, 15222
- Sandcastle Waterpark
- 1000 Sandcastle Drive, Pittsburgh, PA, 15120
- Savoy
- 2623 Penn Avenue, Pittsburgh, PA, 15222
- Scaife Hall (University Of Pittsburgh)
- 3550 Terrrace Street, Pittsburgh, PA, 15261
- ScareHouse (Pittsburgh Mills Mall)
- 590 Pittsburgh Mills Circle, Tarentum, PA, 15084
- Schenley Park
- Frew Street, Pittsburgh, PA, 15213
- Schenley Plaza
- 4100 Forbes Avenue, Pittsburgh, PA, 15260
- Sebco Building
- 819 Liberty Avenue, Pittsburgh, PA, 15222
- Senator John Heinz History Center
- 1212 Smallman Street, Pittsburgh, PA, 15222