- Spirit
- 242 51st Street, Pittsburgh, PA, 15201
- Stage AE
- 400 North Shore Drive, Pittsburgh, PA, 15212
- Station Square
- 125 West Station Square Drive, Pittsburgh, PA, 15219
- Stay Gold Books
- 1104 South Braddock Avenue, Pittsburgh, PA, 15218
- Steamworks Creative
- 4967 Route 8, Gibsonia, PA, 15004
- Stephen Foster Memorial (University of Pittsburgh)
- Cathedral Of Learning, Pittsburgh, PA, 15260
- Strand Theater
- 119 North Main Street, Zelienople, PA, 16063
- Strip District (Historic & Business District)
- 1711 Penn Avenue, Pittsburgh, PA, 15222
- Sunken Bus Studios
- 3312 Babcock Boulevard, Pittsburgh, PA, 15237
- Sweetwater Center For The Arts
- 200 Broad Street, Sewickley, PA, 15143