- Shadyside Presbyterian Church
- 5121 Westminister Place, Pittsburgh, PA, 15232
- Shenot Farm & Market
- 3754 Wexford Run Road , Wexford, PA, 15090
- Sheraton At Station Square
- 230 West Station Square Drive, Pittsburgh, PA, 15219
- Sienna Mercato
- 942 Penn Avenue, Pittsburgh, PA, 15222
- Silver Eye Center For Photography
- 4828 Penn Avenue, Pittsburgh, PA, 15224
- Simple Greek, The (Market Square)
- 431 Market Street, Pittsburgh, PA
- Sixth & Penn Garage
- 546 Penn Avenue, Pittsburgh, PA, 15222
- Smiling Moose
- 1306 East Carson Street, Pittsburgh, PA, 15203
- Smithfield United Church Of Christ
- 620 Smithfield Street, Pittsburgh, PA, 15222
- Soldiers & Sailors Memorial Hall
- 4141 Fifth Avenue, Pittsburgh, PA, 15213