- Ellsworth Avenue Business District (Shadyside)
- Ellsworth Avenue, Pittsburgh, PA, 15232
- Emerald City
- 213 Smithfield Street, Pittsburgh, PA, 15222
- Emerald View Park (Grandview Park)
- 499 Bailey Avenue, Pittsburgh, PA, 15211
- Energy Innovation Center
- 1435 Bedford Avenue, Pittsburgh, PA, 15219
- EQT Tower & Plaza
- 625 Libery Avenue, Pittsburgh, PA, 15222
- Even Hotel Pittsburgh
- 425 Forbes Avenue, Pittsburgh, PA, 15219
- Excuses
- 2526 East Carson Street, Pittsburgh, PA, 15203
- Fairmont Pittsburgh
- 510 Market Street, Pittsburgh, PA, 15222
- Fat Cat
- 520 East Ohio Street, Pittsburgh, PA, 15212
- Fifth Avenue Place
- 120 Fifth Avenue, Pittsburgh, PA, 15222